Runx transcription factors in neuronal development

bHLH transcription factors function in neuronal development

The development of the multiple cell types of a metazoan organism requires that precursor cells pass through a variety of intermediate cell states as cells become progressively more restricted in their developmental potential. Much remains unknown about how intermediate cell states are established during development, and how the restricted potentials of intermediates allows well-ordered transit...

Repression of CD4 in Thymocytes Transcription Factors Required for the Localization of the Domains in Runx

Intranuclear Trafficking of RUNX/AML/CBFA/PEBP2 Transcription Factors in Living Cells: A Dissertation

The family of runt related transcription factors (RUNX/CbfaiAML/PEBP2) are essential for cellular differentiation and fetal development. RUNX factors are distrjbuted throughout the nucleus jn punctate focj that are assocjated with the nuclear matrix/scaffold and generally correspond with sjtes of active transcrjption. Truncations of RUNX proteins that eliminate the C-terminus including a 3l-ami...

Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers

Transcription factors have traditionally been viewed with skepticism as viable drug targets, but they offer the potential for completely novel mechanisms of action that could more effectively address the stem cell like properties, such as self-renewal and chemo-resistance, that lead to the failure of traditional chemotherapy approaches. Core binding factor is a heterodimeric transcription facto...

Small Molecule Inhibitor of CBFbeta-RUNX Binding for RUNX Transcription Factor Driven Cancers

a r t i c l e i n f o Transcription factors have traditionally been viewed with skepticism as viable drug targets, but they offer the potential for completely novel mechanisms of action that could more effectively address the stem cell like properties , such as self-renewal and chemo-resistance, that lead to the failure of traditional chemotherapy approaches. Core binding factor is a heterodime...